2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-138370
    Boc-NH-PEG4-C2-Boc 2138484-13-4
    Boc-NH-PEG4-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-NH-PEG4-C2-Boc
  • HY-138719
    m-PEG5-Propyne 1101668-41-0
    m-PEG5-Propyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. m-PEG5-Propyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    m-PEG5-Propyne
  • HY-W024365R
    3-tert-Butyl-4-methoxyphenol (Standard) 88-32-4
    3-tert-Butyl-4-methoxyphenol (Standard) is the analytical standard of 3-tert-Butyl-4-methoxyphenol. This product is intended for research and analytical applications. 3-tert-Butyl-4-methoxyphenol is a PROTAC linker, belongs to alkyl/ether class, with insecticidal activity. 3-tert-Butyl-4-methoxyphenol also induced increased activities of glutathione (GSH) S-transferase and epoxide hydrolase in the liver and forestomach tissues of A/HeJ mice, regulating the carcinogen metabolism system.
    3-tert-Butyl-4-methoxyphenol (Standard)
  • HY-141223
    m-PEG19-alcohol 2412813-38-6
    m-PEG19-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    m-PEG19-alcohol
  • HY-202399
    TCO-PEG2-NHS ester 2250217-33-3
    TCO-PEG2-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. TCO-PEG2-NHS ester is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
    TCO-PEG2-NHS ester
  • HY-138321
    Propargyl-PEG6-Br 1973383-30-0
    Propargyl-PEG6-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG6-Br is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG6-Br
  • HY-140060
    Propargyl-PEG7-methane 2730134-74-2
    Propargyl-PEG7-methane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG7-methane is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG7-methane
  • HY-133343
    H2N-PEG12-Hydrazide
    H2N-PEG12-Hydrazide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    H2N-PEG12-Hydrazide
  • HY-140702
    m-PEG-triethoxysilane (MW 1000)
    m-PEG-triethoxysilane (MW 1000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG-triethoxysilane (MW 1000)
  • HY-140458
    Azido-PEG36-acid
    Azido-PEG36-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG36-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG36-acid
  • HY-138408
    BocNH-PEG4-CH2CHO 2708026-80-4
    BocNH-PEG4-CH2CHO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    BocNH-PEG4-CH2CHO
  • HY-140603
    Azide-PEG3-Sulfone-PEG3-azide 2055024-45-6
    Azide-PEG3-Sulfone-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azide-PEG3-Sulfone-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azide-PEG3-Sulfone-PEG3-azide
  • HY-132030
    Benzyl-PEG6-NHBoc 2148295-93-4
    Benzyl-PEG6-NHBoc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Benzyl-PEG6-NHBoc
  • HY-132007
    Propargyl-PEG3-PFP ester 2148295-91-2
    Propargyl-PEG3-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG3-PFP ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG3-PFP ester
  • HY-140500
    m-PEG10-acid 2409969-94-2 98.0%
    m-PEG10-acid is a non-cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG10-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG10-acid
  • HY-140358
    PEG20-Tos 2179113-08-5
    PEG20-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    PEG20-Tos
  • HY-W016087
    Monoethyl pimelate 33018-91-6
    Monoethyl pimelate is a PROTAC linker, which refers to the alkyl/ether composition. Monoethyl pimelate can be used in the synthesis of (S,R,S)-AHPC-Me-C7 ester, a specific BCL-XL PROTAC degrader.
    Monoethyl pimelate
  • HY-140637
    Acrylate-PEG-NH2 (MW 10000)
    Acrylate-PEG-NH2 (MW 10000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Acrylate-PEG-NH2 (MW 10000)
  • HY-132060
    Azido-PEG7-t-butyl ester 2596867-40-0
    Azido-PEG7-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG7-t-butyl ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG7-t-butyl ester
  • HY-133314
    Hydroxy-PEG24-CH2-Boc
    Hydroxy-PEG24-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Hydroxy-PEG24-CH2-Boc
PROTAC Linkers Isoform Comparison

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